Electrical
biosensors for biomedical and biosafety
application
Nanomaterial-biomaterial hybrids based
nanoelectronics
Curriculum
Vitea
Research Interest
1. Electrical biosensors
for biomedical and biosafety application
The research focus of my group is to develop
a new class of biosensor devices and implantable
enzymatic biofuel cells, combining design
of nano sized catalysts, bio-fictionalization,
nanofabrication and optical and electrochemical
techniques, that will provide unparalleled
sensitivity and specificity for the real-time
analysis of biological components.
The biosensor platform is relevant to measurement
of DNA sequence, proteins, enzymes, cancer
cells, drug molecules, bacteria and various
toxins. Different functionalized nanomaterials,
magnetic materials and engineered biomaterials
will be used. The major techniques for nanofabrication
and nano-characterization in my lab include
SEM, AFM, TEM, XPS, Surface-enhanced Raman
and electrochemical measurements. The biosensor
project will include: design of self-assemble
monolayers (SAMs) of biomolecular probes,
magnetic nanoparticle based immunosensors,
impedance sensor for cytotoxic and nanotoxic
assay and DNA-based biosensors. The technology
can be used for biomedical diagnoses, bio/pharma
research, bio-defense, environmental protection,
and food/beverage industries.
2. Nanomaterial-biomaterial
hybrids based nanoelectronics
I. Electron
transfer properties of DNA, protein, cells
and peptides.
II. Self-assembly of biomolecules
to make nanowires and nanocircuits.
III. The
applications of the nanowires in bioelectronics,
such as biofuel cells,
DNA transistors, etc.
The research of biofuel cell will involve
the development of carbon nanotube-metallic
nanoparticle hybrids based enzymatic biofuel
cells.
These biosensor devices and biofuel cells
will lead to novel and powerful tools for
fundamental biological research, ultra-high
throughput drug screening and medical diagnostics
applications.
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