Biomedical Optics and Optical Spectroscopy

Curriculum Vitea

Research Interests:
Dr. Lin’s primary research interest is in developing tissue differentiation techniques based on intrinsic tissue optical and mechanical properties. These techniques can be either one-dimensional (i.e., point detection) or multi-dimensional (i.e., imaging). The potential medical applications for such techniques, once developed, are abundant. For example, they may be used intraoperatively to guide tumor resection and to monitor the progression of a novel therapy.

Currently Dr. Lin is working with several investigators from Miami Children’s Hospital on developing an intraoperative optical guidance system for pediatric brain tumor and epilepsy surgery. In addition, his research team at FIU is developing an in vivo optical technique for grading and delineating an infarct in the heart.

Current Research Projects:

• Optical characterization of neoplastic and epileptogenic brain in pediatric patients
• In vivo differentiation of normal, stunned, hibernating, and scarred myocardium using optical spectroscopy
• Dynamics of tissue optical and mechanical properties
• Tissue vitality assessment using optical spectroscopy

Figure 1: An infarcted rat heart.

Figure 2: Research Interests:

Research Interests:

Figure 2: In vivo (a) fluorescence and (b) diffuse reflectance spectra from normal and infracted rat myocardial tissue. The duration of infarct development was seven days. The solid blue and red lines represent the mean spectra, and the error bars represent standard deviations. The green curves represent the p-values of the Student t-test (two samples, two-tails, unequal variance). The yellow boxes highlight the spectral regions with p < 0.01.

Selected Publications:

1. WC Lin, DI Sandberg, S Bhatia, M Johnson, G. Morrison, J Ragheb, “Optical spectroscopy for in vitro differentiation of pediatric neoplastic and epileptogenic brain lesions, ” Journal of Biomedical Optics, in review.
   
   
2. Y Ti, WC Lin, “Effects of probe contact pressure on in vivo optical spectroscopy,” Optics Express, in press.
   
   
3. SK Majumder, S Gebhart, MD Johnson, R Thompson, WC Lin, A Mahadevan-Jansen, “A probability-based spectroscopic diagnostic algorithm for simultaneous discrimination of brain tumor and tumor margins from normal brain tissue,” Applied Spectroscopy, 2007 May; 61(5):548-57.
   
   
4. DJ Parekh, WC Lin, SD Herrell, “In vivo assessment of radio frequency induced thermal damage of kidney using optical spectroscopy,” Journal of Urology, 2006 Oct;176(4):1626-1630.
   
   
5. S Gebhart, WC Lin, A Mahadevan-Jansen, “Normal and neoplastic brain tissue optical properties using inverse adding-doubling,” Physics in Medicine and Biology, 2006 Apr 21;51(8):2011-27.
   
   
6. SA Toms, P Konrad, WC Lin, RJ Weil, “Neuro-oncological applications of optical spectroscopy”, Technology in Cancer Research and Treatment 5: 231 – 238.
   
   
7. DJ Parekh, WC Lin, SD Herrell, “Optical spectroscopy characteristics can differentiate benign and malignant renal tissues: A potentially useful modality,” Journal of Urology, 2005 Nov;174(5):1754-8.
   
   
8. SA Toms, WC Lin, RJ Weil, MD Johnson, ED Jansen, A Mahadevan-Jansen, “Intraoperative Optical spectroscopy identifies infiltrating glioma margins with high sensitivity,” Neurosurgery, 2005 Oct;57(4 Suppl):382-91; discussion 382-91.
   
   
9. WC Lin, M Johnson, RJ Weil, A Mahadevan-Jansen, SA Toms, “In vivo optical spectroscopic detection of radiation injury in brain tissue,” Neurosurgery, 2005 Sep;57(3):518-25; discussion 518-25.
   
   
10. S Gebhart, A Mahadevan-Jansen, WC Lin, “Experimental and simulated angular profiles of fluorescence and diffuse reflectance emission from turbid media,” Applied Optics, 2005 Aug 10; 44(23):4884-901.
    
    
11. CD Anderson, WC Lin, JT Beckham, A Mahadevan-Jansen, CR Buttemere, MK Washington, DJ Phillips, J Pierce, IB Nicoud, CW Pinson, RS Chari, “Fluorescence spectroscopy accurately detects irreversible cell damage during hepatic radiofrequency ablation,” Surgery, 2004; 136; 524-531.
    
    
12. CD Anderson, WC Lin, CR Buttemere, MK Washington, A Mahadevan-Jansen, J Pierce, IB Nicoud, CW Pinson, and RS Chari, “Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation,” Journal of Gastrointestinal Surgery, 2004; 8: 660-669.
    
    
13. CR Buttemere, RS Chari, CD Anderson, MK Washington, A Mahadevan-Jansen, WC Lin, “In vivo assessment of thermal damage in the liver using optical spectroscopy,” Journal of Biomedical Optics, Vol. 9, No.5, p. 1018-1027, 2004.
    
    
14. WC Lin, CR Buttemere, A Mahadevan-Jansen, “Effects of thermal damage on the in vitro optical and fluorescence characteristics of liver tissues,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 9, No.2, p. 162-170, 2003.
    
    
15. PD O'Neal, GL Cote, M Motamedi, J Chen, WC Lin, “Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids,” Journal of Biomedical Optics, Vol. 8 No. 1. p. 33-39, 2003.
    
    
16. WC Lin, SA Toms, ED Jansen, A Mahadevan-Jansen, “Intraoperative application of optical spectroscopy in the presence of blood,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 7, No. 6, p. 996-1003, 2001.
    
    
17. WC Lin, SA Toms, M Johnson, ED Jansen, A Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochemistry and Photobiology, Vol. 73, No, 4, p. 396-402, 2001.
    
    
18. WC Lin, SA Toms, M Motamedi, ED Jansen, A Mahadevan-Jansen, “Brain tumor demarcation using optical spectroscopy; an in vitro study,” Journal of Biomedical Optics, Vol. 5, No. 2, p. 214-220, 2000.
    
    
19. WC Lin, M Motamedi, AJ Welch, “Dynamics of tissue optics during laser heating of turbid media,” Applied Optics, Vol. 35, No. 19, p. 3413-3420, 1996.
    
    
20. WC Lin, M Motamedi, AJ Welch, “Nonlinear optical behavior of ocular tissue during laser irradiation,” Applied Optics, Vol. 34, No. 34, p. 7979-7985, 1995.