Computational and mathematical modeling, biotransport, signal transduction, cardiovascular and respiratory systems physiology

Curriculum Vitea

Dr. Tsoukias' research interests are in the areas of Computational Medicine and Biology; Systems Physiology; Drug delivery and Biotransport.

Laboratory of vascular physiology and biotransport
http://web.eng.fiu.edu/tsoukiasweb/

The main focus of the laboratory is on the mechanisms that regulate blood flow and pressure in the human body. We investigate the physiology of the microcirculation through the parallel development of theoretical and experimental models. Mathematical modeling guides experimentation and assist in data analysis while in vitro experimental studies provide important modeling parameters and promote further model development. We utilize multiscale computational approaches to provide insights for physiological and pathophysiological function from the cell, to the tissue, to the whole organ level. Our goal is to understand function at the macroscale level (tissue/organ) by integrating mechanisms at the subcellular and molecular level.

Selected Publications:

Tsoukias, N. M., Z. Tannous, A. F. Wilson and S. C. George. Single Exhalation Profiles of NO and CO2 in Humans: Effect of Dynamically Changing Flow Rate. Journal of Applied Physiology 85(2):642-652, 1998.

Tsoukias, N. M. and S. C. George. A Two-Compartment Model of Pulmonary Nitric Oxide Exchange Dynamics. Journal of Applied Physiology 85(2):653-666, 1998.

Tsoukias, N. M. and S. C. George. A Single Breath technique with variable flow rate to characterize Nitric Oxide Exchange Dynamics in the Lungs. Journal of Applied Physiology 91(1):477-487, 2001.

Tsoukias, N.M. and A.S. Popel. Erythrocyte consumption of Nitric Oxide in the presence and absence of plasma-based Hemoglobin. American Journal of Physiology 282(6):H2265-77, 2002.

Kavdia M., N.M. Tsoukias and A.S. Popel. A model of Nitric Oxide diffusion in an arteriole: impact of hemoglobin based blood substitutes. American Journal of Physiology 282(6):H2245-53, 2002.

Tsoukias, N.M. and A.S. Popel. A model of nitric oxide capillary exchange. Microcirculation 10(6): 479-95, 2003.

Tsoukias, N.M., M. Kavdia and A.S. Popel. A theoretical model of nitric oxide transport in arterioles: frequency vs amplitude dependent control of cGMP formation. American Journal of Physiology 286(3):H1043-56, 2004.

Kapela, A.., Tsoukias N.M. and A. Bezerianos. New aspects of vulnerability in heterogeneous models of ventricular wall and its modulation by loss of cardiac sodium channel function. Medical & Biological Engineering & Computing 43(3):387-94, 2005.

Ji, J.W., N.M. Tsoukias, D. Goldman, and A.S. Popel. A computational model of oxygen transport in skeletal muscle for sprouting and splitting modes of angiogenesis. Journal of Theoretical Biology 241(1):94-108, 2006.

Tsoukias, N. M., D. Goldman, A. Vadapalli, R. N. Pittman and A. S. Popel. A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three dimensional microvascular networks (submitted), 2006.

Silva H.S., A. Kapela and N.M. Tsoukias.A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells. (submitted), 2006.