BME 4050L

Course title: Biomedical Engineering Laboratory 1

Instructor: James Byrne

Abbreviated Course Title (19 spaces or less):

BME Lab 1

Catalog Description (200 spaces or less):

Emphasis on design, implementation and analysis of biomedical experiments, including biomechanics, tissue mechanics, fluid transport, cardiovascular hemodynamics, and mechanics and materials for artificial organs and implants.

Course Objectives:

BME Lab 1 complements and reinforces material presented in BME 3032, BME 3710 and BME 3700 through the application of multivariable calculus and appropriate statistical tools to modeling data. Students design and conduct experiments and analyze and interpret data involving biomechanics and biomedical fluid systems. Students develop skill in the use of modern engineering tools and address problems associated with the interaction between living and non-living materials and systems. Students must work effectively with others in a team while simultaneously maintaining independent and creative thought. Students must demonstrate an ability to communicate effectively and to articulate technical matters using verbal, written and graphics techniques.

Major Topics:

Measurement of blood viscosity fit to Casson model
Tendon mechanics fit to the Standard viscoelastic model.
Use of a spectrophotometer to measure optical absorption by a solution to verify the Beer-Lambert law.
A Windkessel model is compared to performance of a Vivitro Cardiovascular left ventricle and circulatory system simulator.
Pulmonary Function, volumes and capacities.

Co-requisites:

BME 3032

Prerequisites:

BME 3710, BME 3700.

Contact Hours per Week: Lecture: ___0__ , Lab: __2.75___ , Field Work: ___0__

Textbook(s):

1. Handouts

2. Biopac Student Lab Version 3.0.3, Biopac Systems Inc.

Recommended:

3. Matlab and Simulink 14 – Student Version (software)

Office Hours: T,F 2:00-3:00 PM W 10:30-11:30 AM

Points Distribution:

Report Grading Criteria:

Title Information, 2 %

Objectives Section 3 %

Background 5%

Methods Section 15 %

Calculations 10%

Results and Conclusions 10%

Figures and Tables 30%

Participation and Teamwork 5%

Style 5 %

Spelling and Grammar 10 %

Appendix 5%

Course Grading Criteria:

Experimental Summary Reports 90%

Peer Assesments 10%

The instructor will divide the class into groups having three or four members. Each group will meet on a schedule published in this syllabus. Attendance is mandatory and will be taken in writing before class begins. Late arrival for class will mean 5% will be deducted from your report grade. Unexcused absence will not be tolerated, no make ups will be allowed. Excused Absence must be arranged in advance, to permit attendance in a different group. Absence due to accident or illness will be excused only if a police report of an accident or a doctor’s report for an appointment is provided to the instructor. No make up labs will be given, but following an absence, or in anticipation of a doctors’ appointment, prior arrangements must be made to attend another session if available. Do not just show up unannounced, as you will not be admitted.

All assignments must be turned in to the instructor as both hard copy and electronically by e-mail in word document format.

Turn in your reports two weeks after the lab is conducted, at or before class time. The electronic time stamp on the e-mailed copy will be the official time stamp for determining if the report was turned in on time. Late lab reports will not be accepted, period.

Report grading is done by the teaching assistants according to the Laboratory Report Format, scoring is done on a grading worksheet. An example grading worksheet, Laboratory Report Format and sample report will be issued to the class for reference.

The TA will return the graded reports to the instructor one week after they are turned in. The instructor will record grades and distribute reports. Students will thus have proper feedback to improve subsequent reports.

Five lab exercises will be conducted during the term, so each group will meet alternately as per the schedule. A contingency day is in the calendar to permit completion of any lab that has had to be cancelled for technical reasons or because of unexpected closure of the University for weather or other emergencies. All students are required to attend the last class meeting.

Completion of FIU’s online laboratory safety training will be required of all students. Evidence of completion shall be a print out from the training website showing mastery of the course material. The first class session will be devoted to enrolling in and beginning these safety courses. You must complete all of the below listed certifications or you will receive an F in the class. The work should be completed and evidence of completion provided to the instructor within three weeks of the beginning of the semester.

Most students were preregisterd by the instructor before classes began. For later enrollees, you may register for these on the Environmental Health and Safety Web site at http://www.fiu.edu/~ehs/safety_training/training_course_list.htm

The courses completed shall be:

1004 Laboratory Safety
Hazard Communication
1003 Bloodborne Pathogens Exposure Control
1008 FIU Hazardous Waste Management Training

Items1 through 4 are accessible through http://www.fiu.edu/~ehs/safety_training/training_course_list.htm

All students shall earn a certificate in each before they may participate in laboratory experiments. Upon successful completion of the course a page showing that the student has completed the material is displayed. Print out this page showing you name and the course completed and present it to the instructor. An official certificate will be mailed to me by EH&S for the courses that they offer. I will copy the certificate for my files and deliver the original to the students.

This certificate may be used at this or other institutions as evidence of lab safety training.

The five lab exercises we will perform are:

Pulmonary Function Measurement

· Biopac Pulmonary Function system calibration and operation.

· Measurement or calculation of selected pulmonary volumes and capacities.

· Comparison of observed values of subjects differing in age, sex, weight and height.

This laboratory provides experience with physiological measurements with living subjects

Objectives met: 1, 2, 4, 5, 6, 7, 8, 9

Beer-Lambert Law

· Prepare a quantitative serial dilution of absorptive dyes.

· Learn to use and calibrate the UV-Vis spectrophotometer

· Determine the molar extinction coefficient of the dyes.

· Students will check the predictions of the Beer Lambert Law

Objectives Met: 1,2,5,6,7,8

Soft Tissue Mechanics

· Elastic Modulus and ultimate tensile strength of animal tendon at different strain rates.

· Measure Viscoelastic properties of cartilage.

This lab provides experience with the Enduratec ELF 3200 Tensile Test Machine.

Objectives Met: All of the objectives of the course are met in the course of this laboratory exercise.

Modeling Cardiovascular Fluid Dynamics

· Numerical modeling of windkessel, valve flow and pressure measurements.

· Experimental modeling of windkessel model using Vivitro Systems. Left Heart Simulator

Objectives Met: All of the objectives of the course are met in the course of this laboratory exercise.

Blood Rheology

· Determination of hematocrit.

· Viscometry of blood with Brookfield DV II+.

These experiments provide experience with transport and fluid mechanics, instrumentation on living tissue (animal blood).

Objectives met: 1, 3, 5, 6, 8, 9

BME 4050 L Class Calendar Fall 2005

Week	Week of	Group 1	Group2	Group 3	Group 4	Notes
1	Aug 30	Introductory Lecture Lab Safety Course Online	Introductory Lecture Lab Safety Course Online	Introductory Lecture Lab Safety Course Online	Introductory Lecture Lab Safety Course Online	Safety Courses Prearranged with EHS and workstations available from EIC
2	Sept 6	Pulmonary Function, Brown	Beer’s Law, Godavarty	Off	Off	Add/Drop End
3	Sept 13	Off	Off	Pulmonary Function, Brown	Beer’s Law, Godavarty
4	Sept 20	Beer’s Law, Godavarty	Pulmonary Function, Brown	Off	Off	G1G2 R1 Due/ All Safety Courses Due
5	Sept 27	Off	Off	Beer’s Law, Godavarty	Pulmonary Function, Brown	G3G4 R1 Due G1G2 R1 GradeDue
6	Oct 4	Cardiovascular Mechanics, Schoephoerster	Viscoelastic Properties of Tendon, Crumpler	Off	Off	G3G4 R1 GradeDue
7	Oct 11	Off		Cardiovascular Mechanics, Schoephoerster	Viscoelastic Properties of Tendon, Crumpler	G3 G4 R2 Due
8	Oct 18	Viscoelastic Properties of Tendon, Crumpler	Cardiovascular Mechanics, Schoephoerster			G1 G2 R3 Due, G3G4 R2 GradeDue
9	Oct 25	Off	Off	Viscoelastic Properties of Tendon, Crumpler	Cardiovascular Mechanics, Schoephoerster	G3 G4 R3 Due G1G2 R3 GradeDue
10	Nov 1	Blood Rheology Byrne		Off	Off	Drop w/DR ,G1 G2 R4 Due G3G4 R3 GradeDue
11	Nov 8	Off	Blood Rheology Byrne	Off	Off	G3 G4 R4 Due G1G2 R4 GradeDue
12	Nov 15	Contingency	Off	Blood Rheology Byrne	Off	G1 R5 Due G3G4 R4 GradeDue
13	Nov 22	Off	Contingency	Contingency	Blood Rheology Byrne	G2 R5 Due G1R5 GradeDue
14	Nov 29	Off	Off	Off	Contingency	G3 R5 Due, G1 G2 Contingency Due G2 R1 GradeDue
15	Dec 6	Off	Off	Off	Off	G 4 R5 Due G3 Contingency Due G3 R5 GradeDue, G3 Contingency GradeDue
16	Dec 13	Evaluations, Byrne	Evaluations, Byrne	Evaluations, Byrne	Evaluations, Byrne	Exam Week G4 Contingency Due G4 R5 and G3 Contingency Grade Due, G4 Contingency And all Evals Grade Due