BME 6750 – Artificial Organs: 3 Credits.
Textbook: Lecture material will come from Artificial Organs journal.
Available online through FIU library http://www.blackwell-synergy.com/loi/aor
Recommended: Basic Transport Phenomena in Biomedical Engineering. By Ronald Fournier
Recommended: Transport Phenomena in Biological Systems. By Truskey, Yuan and Katz
Coordinator: Anthony J McGoron
Office hours: Tu-W-Th
This course will examine applications of mass and fluid transport, biomaterials, biomechanics, and mass transport modeling to the design and analysis of artificial organs. Students will be introduced to tissue engineering as applied to artificial organ design, review transport modeling as applied to artificial organs, and review the literature to be able to understand current examples of artificial organs.
Prerequisites: EGM 5585 - Biotransport.
1. Students will know the design considerations of a bioartificial organ.
2. Students will be able to develop a mathematical model of various physiological systems.
3. Students will be able to develop a mathematical model of an artificial organ.
4. Students will be able to implement the mathematical model numerically using a computer.
5. Students will be able to describe the design and application of an artificial organ.
Grading scale: 95-100 A; 90-94.9 A-; 86-89.9 B+; 82-85.9 B; 78-81.9 B-; 74-77.9 C+; 70-73.9 C; 66-69.9 C-; 62-65.9 D+; 51.9-58 D
Policy regarding student
misconduct: Students at
Any student who must miss the exam needs to notify the instructor or departmental secretary prior to exam time and have documentation for the reason.
Turn off cell phones before entering class.
Syllabus for Artificial Organs
Grading will consist of 1 midterm exam (25%), a review and presentation of an example of a specific artificial organ from the literature (25%), and a class project using computer modeling and simulation software (25%). Midterm exam will be for 1 hour and 15 minutes. The exam may consist of quantitative problems, as well as some multiple choice, fill in the blank and/or short essay questions. There will be no final exam. The tentative course syllabus is given below. Dates of mid-term exams and due dates for the projects will be decided during the semester. Attendance will account for 20% of the final grade. Two absences will be allowed without penalty. After that, 5 points will be deducted from your final score for each additional absentee without prior approval. Participation in classroom discussion will count for 5% of the final grade.
The order in which students will be required to give presentations will be determined by a lottery during the 2nd week of class, unless students want to volunteer to present early.
2-5 Tissue Engineering – Fournier Chapter 7
6-9 Bioartificial Organs – Fournier Chapter 8
10-11 Instructor presentation of an artificial organ designs from the literature
12-13 Computational Modeling and Simulations of Bioartificial Organs
15-22 Student presentations and discussions of artificial organ designs from the literature
22-28 Student presentations and discussions of computer projects
Prepare a PowerPoint presentation/lecture to the class describing an artificial organ. Choose one specific journal article, but include information from other sources and compare the device in the main journal paper to other devices. The relevant article will be distributed to the entire class before the lecture so that all students will be able to participate in the discussion. The presentation will be 45 minutes, followed by 30 minutes of open discussion. The presentations must be in PowerPoint, but use of the dry eraser board to for additional explanation of points is highly encouraged. Favorable consideration will be given to presenters that use reference material in addition to the original article for their presentation. Reference material must be from textbooks or peer reviewed journals, i.e., not from internet web sites. In other words, your presentation must not depend on information from the internet, though obviously there is a lot of useful information on the internet.
Describe (1) the disease or condition being addressed by the artificial organ, (2) current medical approach to treating the disease (3) a review of the various artificial organ devices described in the literature (4) the biomaterials or biological materials used in the device (5) the materials used in the device that are non-bio (6) blood material or cell material interactions (7) how the device functions (8) any computational modeling of the device function (9) computational modeling of the natural physiological system (10) experimental model used to test the device (11) alternative/competitive devices (12) safety and efficacy considerations. The presentations should concentrate on a specific device design. However, review articles are helpful for comparisons to other devices/designs.
All presentations must be submitted to the instructor as a printout prior to the class so that copies can be distributed to the students, and in electronic form within one week of the presentation.
Computational modeling. Take an artificial organ design described in the literature and model the device using compartmental and/or distributed systems modeling.