BME 4050L       Biomedical Engineering Laboratory 1

Fall 2004

Tuesdays 8:40 AM-11:25 AM

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Instructor:                 James Byrne                  

Office:                         EAS 2612

Phone  348-1409

Email:                         james.byrne@fiu.edu

Textbook:                     Handouts will be provided

Class Description:              

Biomedical Engineering Lab 1 incorporates the implementation of experiments in biomechanics and biomedical fluid dynamics. Topics include:

  1. Measurement of blood viscosity
  2.  Laser Doppler velocity meter theory and flow measurements in vitro
  3. Soft and hard tissue mechanics
  4. Mechanics and materials for artificial organs and implants
  5. A Windkessel model is compared to performance of a Vivitro Cardiovascular                                                               left ventricle and circulatory system simulator

 

Course Objectives:  By the end of this course students should be able to

 

1.      Conduct experiments involving transport, mechanics and instrumentation.

2.      Apply multivariable calculus and differential equations to the design and execution of experiments.

3.      Develop and demonstrate an ability to make measurements on and interpret data from living systems.

4.      Develop skill in the use of modern engineering tools

5.      Analyze and interpret data.

6.      Address problems associated with the interaction between living and non-living materials and systems.

7.      Utilize analytical and experimental methods and modern computer technology for decision-making and to solve realistic biomedical engineering problems.

8.      Work effectively with others in a team while simultaneously maintaining independent and creative thought.

9.      Communicate effectively and to articulate technical matters using verbal, written, and graphic techniques.

 

 

 

 

 

 

 

 

 

 

 

 

 

   Points Distribution:

  Report Grading Criteria:     

Technical Content                                60%

            Figures, Equations, Tables                   30%

            Spelling and Grammar                          5%

            Style (impress me points)                      5%  

Course Grading Criteria:

           Experimental Summary Reports          70%

            Short Engineering Report                     30%

 

Attendance is mandatory and will be taken in writing before class begins. Late arrival will mean 5% will be deducted from your report. If you miss a lab there will be no make up. The instructor will retain copies of graded lab reports. Lab reports must be turned in two weeks following the experiment, reports must be turned in as hard copy and electronically in MS word format, by disk or e-mail with graphics embedded in the file.  Software assignments may be turned in as prints outs and text files.  Late lab reports will not be accepted. Grading is done on an equally weighted line, D- gets 1 point, and A+ gets 12 points. Averages are to the nearest point, rounding is 1.5 rounds to 1, 1.51 rounds to 2.

 

Completion of FIU’s online laboratory safety training will be required of all students. You may register for these on the Environmental Health and Safety  Web site at http://www.fiu.edu/~ehs/safety_training/training_course_list.htm

The courses completed shall be:

1.        1004 Laboratory Safety

2.        Hazard Communication

3.        1003 Bloodborne Pathogens Exposure Control

4.        1008 FIU Hazardous Waste Management Training

5.        Research Involving Animals

Items 1 through 4 are accessible through http://www.fiu.edu/~ehs/safety_training/training_course_list.htm

Item 5 is accessible through http://www.dsrt.fiu.edu/animalsubjects/animal_subjects.htm

All students shall earn a certificate in each before they may participate in laboratory experiments. Evidence of completion shall be a print out from the training website showing mastery of the course material.  A certificate will be mailed to me by EH&S or DSRT after completion of the courses.  I will copy the certificate for my files and deliver the original to the students.  This certificate may be used may be used at this or other institutions as evidence of lab safety training.

 

Tentative Course Outline:

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 Five laboratory exercises will be performed from the following list:

Blood Rheology

·         Determination of hematocrit.

·         Viscometry of blood with Brookfield DV II+.

These experiments provide experience with transport and fluid mechanics, instrumentation on living tissue (animal blood).

Objectives met: 1, 3, 5, 6, 8, 9

 

Laser Doppler Velocimetry

 ·         Biopac fiber optic LDV system theory and operation.

·         Laminar Flow in a rectangular duct, theory.

·         Laminar flow measurements in a rectangular duct using LDV.

This laboratory provides experience with transport and optical instrumentation

Objectives met: 1, 2, 4, 5, 6, 7, 8,

 

Soft Tissue Mechanics

·        Elastic Modulus and ultimate tensile strength of animal tendon at different strain rates.

·        Measure Viscoelastic properties of cartilage.

·          Fit Viscoelastic Voight or Kelvin Model to Data via MATLAB©

This lab provides experience with the Enduratec ELF 3200 Tensile Test Machine.

Objectives Met:  All of the objectives of the course are met in the course of this laboratory exercise.

 

 

 

Hard Tissue Mechanics

·       Determine anisotropy of some mechanical properties of cortical bone.

·         Measure Elastic Modulus and ultimate strength of cortical bone in compression. In 3 axes

This lab provides experience with the Enduratec ELF 3200 Tensile Test Machine.

Objectives Met:  1,3,4,5,6,8,9

 

 

Modeling Cardiovascular Fluid Dynamics

·        Numerical modeling of windkessel, valve flow and pressure measurements.

·         Experimental modeling of windkessel model using Vivitro Systems. Left Heart Simulator

Objectives Met:  All of the objectives of the course are met in the course of this laboratory exercise.

 

 

 

 

 

 

 

 

 

 

 

Week

Week of

Group 1

Group2

1

Aug 31

Introductory Lecture Lab Safety Online Course

Introductory Lecture Lab Safety Online Course

2

Sept 7

Laser Doppler Velocimetry 1

 

3

Sep 14

 

Laser Doppler Velocimetry 1

4

Sept 21

Blood Rheology

 

5

Sept 28

 

Blood Rheology

6

Oct 5

Soft Tissue Mechanics Lab- Tendon

 

7

Oct 12

 

Soft Tissue Mechanics Lab- Tendon

8

Oct 19

Soft Tissue Mechanics -Cartilage

 

9

Oct 26

 

Soft Tissue Mechanics -Cartilage

10

Nov 2

  Cardiovascular Fluid Mechanics 

 

11

Nov 9

 

Cardiovascular Fluid Mechanics 

12

Nov 16

 

 

13

Nov 23

Short Engineering Report Due

 

14

Nov 30 

 

Short Engineering Report Due

15

Dec 7

Semester Review and Questions:

Semester Review and Questions