BME-3032 – Biomedical Engineering Transport Spring 2004, Class Meets: MW 2:40-3:55 ______________________________________________________________________________
Instructor: Anthony McGoron Office: EC
2671 Phone: 348-1352 Office
Hours 12:30-2:30 Tu-Wed-Th, or by appointment email: Anthony.Mcgoron@fiu.edu Textbook: Required Transport Phenomena in Biological Systems By: Truskey, Yuan and Katz Recommended Transport Phenomena By: William Thomson Course Description: Basic principles of heat, mass,
and momentum (fluid) transport phenomena. Topics include elements of
heat, mass, and momentum transfer in physical and physiological systems,
pharmacokinetics and drug delivery, hemodialysis, clinical use of enzymes,
separation of biological substances as well as modeling of physiological
processes and artificial organs. Biotransport applications to artificial
organs, and physiological systems modeling concentrating on cardiovascular
hemodynamics. Design of the artificial lung, kidney, liver and pancreas.
Computer models of transport phenomena using Matlab and Simulink. There
will be 3 exams and 2 reports (20% each). Homework problems will be assigned
throughout the semester but will not be graded.
Course Objectives: By the end of this course, students should: 1. Understand the mechanisms of the transport process. 2. Be able to apply advanced mathematics and physics to solving transport problems in both physiological and nonphysiological systems. 3. Be able to derive the basic differential equations describing the transport phenomena laws. 4. Formulate equations for the micro and marco analysis of transport problems. 5. Be able to apply numerical techniques to solve transport problems. 6. Be able to use the principles of transport phenomena in the design of artificial organs and devices.
7.
Learn to communicate ideas effectively through required class assignments.
Grading scale: 95-100
A; 90-94.9 A-; 86-89.9 B+; 82-85.9 B; 78-81.9 B-; 74-77.9 C+; 70-73.9
C; 66-69.9 C-; 62-65.9 D+; 58-51.9 D
Policy regarding student misconduct: Students at Florida International University are expected to adhere
to the highest standards of integrity in every aspect of their lives.
Honesty in academic matters is part of this obligation. Academic integrity
is the adherence to those special values regarding life and work in
an academic community. Any act or omission by a student which violates
this concept of academic integrity shall be defined as academic misconduct
and shall be subject to the procedures and penalties established by
the university. Students violating academic integrity will
receive a failing grade for the course and the incident will be forwarded
to Student Academic Affairs. Academic misconduct includes, but
is not limited to, copying homework, copying work on exams either in-class
or take-home, copying of projects, or plagiarism. Plagiarism is using
others' ideas and words without clearly acknowledging the source of
that information. This includes, but is not limited to, the internet,
textbooks, journals, or any other material that is not your own work.
It is the responsibility of students to report misconduct, which may
include another student copying from your, or another student’s exam,
homework, projects or any other assignment. Therefore, if a student
copies from you, it is your responsibility to report it, otherwise
you are also responsible. Under no circumstances will any student be
permitted to leave and return to the classroom during an exam.
Turn off cell phones before entering class. Points Distribution: Project 1 20% Project
2 20% Exam 1 20% Exam 2 20% Exam 3 (final) 20% ______________________________________________________________________________ Tentative Course Outline
Lecture Topic
1
Transport phenomena laws,
differential balances and the conservation laws: (handout)
2
Definition of transport processes:
Sections 1.2-1.3
3
Fluid kinetics: Section 2.2
4
Conservations relations and
BC’s -Fluid statics: Sections 2.3-2.4
5
Constitutive relations-Laminar
and turbulent flow: Sections 2.5-2.6
6
Applications of momentum
balances-Rheology and flow of blood: Sections 2.7-2.8
7
Differential form of conservation
of mass and momentum: Sections 3.2-3.3
8
Fluid motion with more than
one dependent variable: Section 3.4
9
Solute fluxes in mixtures-conservations
relations: Sections 6.2-6.3
10
Steady-state and unsteady-state
diffusion in one dimension: Sections 6.7-6.8
11
Review
12
Exam 1
13
Fick’s law of diffusion and
solute flux-dimensional analysis: Sections 7.1-7.2
14
Electrolyte transport-Diffusion
and convection: Section 7.4-7.5
15
Macroscopic form of conservation
relation-Mass transfer coefficients: Sections 7.6-7.7
16
Mass transfer across membranes:
Section 7.8
17
Enzyme kinetics: Section
10.4
18
Oxygen-hemoglobin equilibria
and binding kinetics: Sections 13.2-13.3
19
Dynamics of oxygenation of
blood in lung-Oxygen delivery to tissue: Section 13.4-13.5
20
Review
21
Exam 2
22
Mechanisms of transmembrane
transport: Section 14.2
23
Quantitative analysis of
glomerular filtration: Section 14.4
24
Quantitative analysis of
tubular reabsorption: Section 14.5
25
A whole organ approach to
renal modeling: Section 14.6
26
Pharmacokinetic analysis-Simple
compartmental models: Sections 16.2-16.3
27
Physiologically based pharmacokinetic
models: Sections 16.4
28
Review
29
Final Exam |