EGM 6589 ADVANCED
BIOFLUID MECHANICS
SPRING 2005
__________________________________________________________________
INSTRUCTOR: Richard T. Schoephoerster
OFFICE: EC 2602 PHONE:
348-3722 EMAIL:
schoepho@fiu.edu
OFFICE HOURS: M-F
COURSE OBJECTIVE
This
course is designed as the pinnacle course in the biofluids
area at FIU and as such will provide the student with the most advanced
theories related to biological fluid flow phenomena, including an inspection of
the most up to date research in this area.
COURSE LEARNING OUTCOMES
By the end of this course, each student should be able to:
1.
Develop and use
mathematical models of the human circulatory system in its natural and various
pathological conditions.
2.
Display an
understanding of the basic fluid mechanical mechanisms involved in
cardiovascular disease development.
3.
Develop a sound
research proposal on a topic related to biofluid
mechanics.
4.
Communicate
effectively all of the above in oral and written form.
COURSE DESCRIPTION
This course will take a
somewhat historical timeline by beginning with the most basic models of arterial blood flow, and then adding complexities to produce
more realistic models for analysis.
Topics to be covered include the following:
I. Governing Equations for Fluid Flow; Poiseuille
Flow
II. Turbulence
III. Unsteady Flow; Womersly solution
IV. Elastic Tubes
A. Impedance, Windkessel
B. Wave Propagation, Reflection
V. Flow Dynamics and the Arterial Wall
VI. Formed Elements in the Blood
A. Effects of Cells on Flow
B. Effects of Flow on Cells, Molecules
POINTS DISTRIBUTION: Paper
Reviews and Presentations 50%
Research
Proposal 50%
References
TURBULENCE, UNSTEADY FLOW, IMPEDANCE, WAVE
PROPAGATION, REFLECTION
Nichols
and O'Rourke McDonald's
Blood flow in Arteries
Lea & Febiger
Milnor Hemodynamics
Williams and Wilkens
EFFECTS OF CELLS ON FLOW (AND VICE VERSA)
Goldsmith and Turitto
(1986) "Rheological aspects of thrombosis and haemostasis: Basic
principles and applications," Thrombosis and Haemostasis,
55:415-435.
Ramstack, Zuckerman, and Mockros (1979) "Shear-induced activation of
platelets," Journal of Biomechanics, 12:113-125.
Turitto and Baumgartner (1975) "Platelet deposition on subendothelium exposed to flowing blood: Mathematical analysis of physical
parameters," ASAIO Transactions, 21:593-601.
Eckstein and Belgacem
(1991) "Model of platelet transport in flowing blood with drift and
diffusion terms," Biophysical Journal, 60:53-69.
Basmadjian (1990) "The effect of flow
and mass transport in thrombogenesis," Annals
of Biomedical Engineering, 18:685-709.
Basmadjian (1989) "Embolization:
Critical thrombus height, shear rates, and pulsatility.
Patency of
blood vessels," Journal of Biomedical Materials Research,
23:1315-1326.
Schoephoerster, Oynes,
Nunez, Kapadvanjwala, and Dewanjee
(1993) "Effects of local geometry and fluid dynamics on regional platelet
deposition on artificial surfaces."
Arteriosclerosis and Thrombosis, 13:1806-1813.
FLOW DYNAMICS AND THE ARTERIAL WALL
Fry (1968) "Acute vascular
endothelial changes associated with increased blood velocity gradients,"
Circulation Research, 22:165-197.
Caro Fitz-Gerald, and Schroter (1971) "Atheroma and arterial wall shear. Observation, correlation, and proposal of a
shear-dependent mass transfer mechanism for atherogenesis,"
Proceedings of the Royal Society of London, B177:109-159.
Friedman, Deters, Bargeron, Hutchins, and Mark (1986) "Shear-dependent
thickening of the human arterial intima," Atherosclerosis,
60:161-171.
Friedman (1989) 'A biologically
plausible model of thickening of arterial intima
under shear," Arteriosclerosis, 9:511-522.
Weinbaum, Tzeghai, Ganatos, Pfeffer, and Chien (1985) Effect of cell turnover and leaky junctions on
arterial macromolecular transport," American Journal of Physiology,
248:H945-H960.
Journal of Biomechanical Engineering (1993) Special Issue: 20th Anniversary Biomechanics Symposium,
Volume 115, Number 4(B).