BME-3992 – Biomedical Engineering Transport
Fall 2003, Tu-Th 11:40-12:55
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INSTRUCTOR: Anthony McGoron
OFFICE: EAS 2671 PHONE: 348-1352
Office Hours 9:30-11:30 Tu-Wed-Th
EMAIL: Anthony.Mcgoron@fiu.edu
Textbook: Required
Introduction to Transport Phenomena
By: William Thomson
Class Description:
Basic principles of heat, mass, and momentum (fluid) transport phenomena. Topics include elements of heat, mass, and momentum transfer in physical and physiological systems, pharmacokinetics and drug delivery, hemodialysis, clinical use of enzymes, separation of biological substances as well as modeling of physiological processes and artificial organs. Biotransport applications to artificial organs, and physiological systems modeling concentrating on cardiovascular hemodynamics. Design of the artificial lung, kidney, liver and pancreas. Computer models of transport phenomena using Matlab and Simulink. There will be 3 exams (15% each). Homework problems will be assigned throughout the semester (15% total). Two projects will be assigned (20% each).
Course Objectives:
By the end of this course, students should:
1. Understand the mechanisms of the transport process.
2. Be able to apply advanced mathematics and physics to solving transport problems in both physiological and nonphysiological systems.
3. Be able to derive the basic differential equations describing the transport phenomena laws.
4. Formulate equations for the micro and marco analysis of transport problems.
5. Be able to apply numerical techniques to solve transport problems.
6. Be able to use the principles of transport phenomena to understand the design of artificial organs and devices.
7. Learn to communicate ideas effectively through required class assignments.
POINTS DISTRIBUTION: Report 1 20%
Report 2 20%
Assignments 15%
Exam 1 15%
Exam 2 15%
Exam 3 15%
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Lecture Topic
1 Introduction: Chapter 1
2 Transport phenomena laws: Sections 2.1-2.2
3 Transport phenomena laws: Section 2.3
4 One-dimensional molecular energy transport: Sections 3.1-3.2
5 Steady-State and unsteady-state energy transport: Sections 3.3-3.4
6 Molecular mass transport: Sections 4.1-4.2
7 Molecular mass transport: Sections 4.3-4.4
8 Molecular mass transport: Sections 4.5-4.6
9 Enzyme kinetics – The artificial liver (handout)
10 Exam 1
11 Molecular momentum transport: Sections 5.1-5.3
12 Molecular momentum transport: Sections 5.4 and 6.4
13 Transport coefficients in multicomponent mixtures: 6.3
14 Non-Newtonian fluids and blood rheology: Section 6.4
15 Convective transport in laminar flow, developing flow in a pipe: Sections 8.1-8.3
16 Energy transport in a shell and tube, plug flow chemical reactor: Sections 8.2-8.3
17 Transfer coefficients: Sections 10.1-10.3
18 Blood flow in the heart, arteries and veins (handout)
19 Exam 2
20 Macroscopic calculation in mass transport: Sections 13.1
21 Mass transfer in gas absorbers and strippers: Sections 13.2a-13.2.2b
22 Generalized equations of change: Appendix A
23 Differential vs integral approach to transport phenomena (handout)
24 Blood flow in extracorporeal devices (handout)
25 Design of the artificial lung/oxygenator (handout)
26 Design of the artificial kidney and pancreas (handout)
27 Pharmacokinetics and drug delivery (handout)
28 Pharmacokinetics and drug delivery continued
29 Final Exam