|Chenzhong Li, Ph.D.
(305) 348-6954 Fax
Electrical biosensors for biomedical and biosafety application
Nanomaterial-biomaterial hybrids based nanoelectronics
1. Electrical biosensors for biomedical and biosafety application
The research focus of my group is to develop a new class of biosensor devices and implantable enzymatic biofuel cells, combining design of nano sized catalysts, bio-fictionalization, nanofabrication and optical and electrochemical techniques, that will provide unparalleled sensitivity and specificity for the real-time analysis of biological components.
The biosensor platform is relevant to measurement of DNA sequence, proteins, enzymes, cancer cells, drug molecules, bacteria and various toxins. Different functionalized nanomaterials, magnetic materials and engineered biomaterials will be used. The major techniques for nanofabrication and nano-characterization in my lab include SEM, AFM, TEM, XPS, Surface-enhanced Raman and electrochemical measurements. The biosensor project will include: design of self-assemble monolayers (SAMs) of biomolecular probes, magnetic nanoparticle based immunosensors, impedance sensor for cytotoxic and nanotoxic assay and DNA-based biosensors. The technology can be used for biomedical diagnoses, bio/pharma research, bio-defense, environmental protection, and food/beverage industries.
2. Nanomaterial-biomaterial hybrids based nanoelectronics
I. Electron transfer properties of DNA, protein, cells and peptides.
II. Self-assembly of biomolecules to make nanowires and nanocircuits.
III. The applications of the nanowires in bioelectronics, such as biofuel cells, DNA transistors, etc.
The research of biofuel cell will involve the development of carbon nanotube-metallic nanoparticle hybrids based enzymatic biofuel cells.
These biosensor devices and biofuel cells will lead to novel and powerful tools for fundamental biological research, ultra-high throughput drug screening and medical diagnostics applications.